Yang Y1, Tian J2, Yang B3.
Autism spectrum disorder (ASD) is a severely neurodevelopmental disorder that impairs a child’s ability to communicate and interact with others. Children with neurodevelopmental disorder, including ASD, are regularly affected by gastrointestinal problems and dysbiosis of gut microbiota. On the other hand, humans live in a co-evolutionary association with plenty of microorganisms that resident on the exposed and internal surfaces of our bodies. The microbiome, refers to the collection of microbes and their genetic material, confers a variety of physiologic benefits to the host in many key aspects of life as well as being responsible for some diseases. A large body of preclinical literature indicates that gut microbiome plays an important role in the bidirectional gut-brain axis that communicates between the gut and central nervous system. Moreover, accumulating evidences suggest that the gut microbiome is involved in the pathogenesis of ASD. The present review introduces the increasing evidence suggesting the reciprocal interaction network among microbiome, gut and brain. It also discusses the possible mechanisms by which gut microbiome influences the etiology of ASD via altering gut-brain axis. Most importantly, it highlights the new findings of targeting gut microbiome, including probiotic treatment and fecal microbiota transplant, as novel and potential therapeutics for ASD diseases.
Autism spectrum disorders; Gastrointestinal problems; Gut microbiome; Gut-brain axis; Probiotics; Therapy
Dr. Manish Bhatia
BHMS, BCA, M.Sc. Homeopathy (UCLAN, UK), CICH (IACH, Greece)
Dr. Manish Bhatia is the Founder Director of Hpathy.com, world’s leading homeopathy portal, serving homeopathy to more than half a million people every month. He is also Editor of Homeopathy for Everyone.
He runs a consultation office at Jaipur (Asha Homeopathy) and is one of the most well known Indian homeopaths globally. He has been practicing since 2001 and is helping Autism and other psychiatric patients since 2006. He was awarded Rajasthan’s foremost Raja Pajvan Dev Award For Excellence in the field of Medicine in 2015.
He has been working as an Asso. Professor of Organon of Medicine at S. K. Homeopathic Medical College since 2002. He was awarded with the prestigious APJ Abdul Kalam State Level Teacher’s Award in 2016. He has also given seminars and webinars in several countries of Europe, Americas and Australia.
He is the author of Lectures on Organon of Medicine Vol. I & II (English, Bulgarian, German editions), which are approved by the Central Council of Homeopathy (India) for BHMS and MD (Hom) syllabus. He is a contributing author to the book “Homeopathy and Mental Health Care: Integrative Practice, Principles and Research” and co-editor of “The Fireside Book of Homeopathy Tales.”